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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
17.88
Human Site:
S387
Identified Species:
28.1
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S387
I
K
K
K
V
H
F
S
G
E
S
K
E
N
I
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S464
I
K
K
K
V
H
F
S
G
E
S
K
E
N
I
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S387
I
K
K
K
V
H
F
S
G
E
S
K
E
N
V
Dog
Lupus familis
XP_537144
668
75595
S610
I
K
K
K
V
H
F
S
G
E
S
K
E
N
V
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
H386
M
K
K
K
V
H
F
H
G
E
S
K
E
N
T
Rat
Rattus norvegicus
XP_001055166
443
51340
H386
L
K
K
K
V
H
F
H
G
E
S
K
E
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
F441
I
T
K
K
K
V
H
F
G
G
E
S
K
E
N
Chicken
Gallus gallus
NP_001026221
444
51581
F386
T
T
K
K
K
V
H
F
G
G
S
E
E
D
G
Frog
Xenopus laevis
NP_001079490
442
52004
S379
D
A
Y
T
E
S
S
S
T
R
S
R
R
H
V
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
N528
H
Q
I
L
A
C
G
N
N
R
F
N
K
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
L456
L
Q
Q
K
L
E
E
L
Q
T
R
E
Q
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
H354
A
E
E
L
I
E
E
H
E
K
Q
Q
K
Q
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
D541
G
V
R
R
Q
R
F
D
P
S
S
Y
Q
Q
R
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
S349
Q
I
R
T
A
R
K
S
L
Q
L
E
R
F
E
Red Bread Mold
Neurospora crassa
P48479
858
94329
T495
S
P
R
R
M
A
L
T
K
A
P
T
T
N
P
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
93.3
N.A.
80
80
N.A.
26.6
33.3
13.3
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
33.3
46.6
33.3
20
N.A.
53.3
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
26.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
14
7
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% D
% Glu:
0
7
7
0
7
14
14
0
7
40
7
20
47
14
7
% E
% Phe:
0
0
0
0
0
0
47
14
0
0
7
0
0
7
0
% F
% Gly:
7
0
0
0
0
0
7
0
54
14
0
0
0
0
14
% G
% His:
7
0
0
0
0
40
14
20
0
0
0
0
0
7
0
% H
% Ile:
34
7
7
0
7
0
0
0
0
0
0
0
0
0
20
% I
% Lys:
0
40
54
60
14
0
7
0
7
7
0
40
20
0
0
% K
% Leu:
14
0
0
14
7
0
7
7
7
0
7
0
0
7
7
% L
% Met:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
7
0
0
7
0
47
7
% N
% Pro:
0
7
0
0
0
0
0
0
7
0
7
0
0
0
7
% P
% Gln:
7
14
7
0
7
0
0
0
7
7
7
7
14
14
0
% Q
% Arg:
0
0
20
14
0
14
0
0
0
14
7
7
14
0
7
% R
% Ser:
7
0
0
0
0
7
7
40
0
7
60
7
0
0
0
% S
% Thr:
7
14
0
14
0
0
0
7
7
7
0
7
7
0
14
% T
% Val:
0
7
0
0
40
14
0
0
0
0
0
0
0
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _